To further understand the role of β-catenin on mediating HDAC7-induced c-Myc upregulation, the specific β-catenin activity inhibitor Lf3 was applied to the ESCC cells, and Lf3 treatment dose-dependently decreased the ESCC cell proliferation (P < 0.05, Fig. 5a). This evidence concerns the gene HDAC7 and esophageal squamous cell carcinoma.