Furthermore, Western blotting analysis showed that the melatonin-induced downregulation of c-Myc and upregulation of p21 and p27 levels was also reversed by HDAC7 overexpression whereas enhanced by HDAC7 knockdown in the melatonin-treated ESCC cells (Fig. 2g). Here, HDAC7 is linked to esophageal squamous cell carcinoma.