Previous studies demonstrated that USP10 could deubiquitinate and stabilize Yes-associated protein (YAP)/PDZ-binding motif (TAZ), HDAC6, FMS-like tyrosine kinase 3 (FLT3), spleen tyrosine kinase (SYK) and topoisomerase Iiα (TOP2α), thus promoting cancer progression [22–26]. The gene discussed is SYK; the disease is cancer.