Importantly, the Kaplan–Meier analyses showed that patients with high coexpression of USP10 and HDAC7 or of USP10 and c-Myc had the worst prognosis; whereas ESCC with low USP10/low HDAC7, and low USP10/low c-Myc showed the best prognosis among the groups (Fig. 7e). Here, MYC is linked to esophageal squamous cell carcinoma.