Consistently, in this study, ectopic HDAC7 expression markedly downregulated the β-catenin acetylation (Lys49) and phosphorylation (Ser675) levels; while HDAC7 knockdown promoted β-catenin acetylation and phosphorylation in ESCC cells (Fig. 4d). The gene discussed is HDAC7; the disease is esophageal squamous cell carcinoma.