MYC and esophageal squamous cell carcinoma: Moreover, the Cox and Kaplan–Meier survival analyses respectively indicated that c-Myc expression was an independent prognostic factor for ESCC patients (HR = 2.233, 95% CI 1.376 – 3.625, P = 0.001, Table 2), and negatively correlated with ESCC overall survival (Log-rank P < 0.001, Fig. 3c).