USP10 and esophageal squamous cell carcinoma: Moreover, both the Kaplan–Meier and Cox survival analyses suggested that USP10 was a negative prognostic factor for ESCC patients (HR = 1.725, 95% CI 1.032–2.885, P = 0.038, Table 2), and higher USP10 level predicted shorter overall survival (Log-rank P < 0.001, Fig. 7c).