Our results are in line with previous studies describing GSDMB [12, 14], Rab7 [51] and LC3 over-expression [52, 53] as poor prognosis cancer factors and reinforce the connection between GSDMB/Rab7/LC3B co-expression, protective autophagy, resistance to anti-HER2 therapies and adverse prognosis in clinical samples. This evidence concerns the gene GSDMB and cancer.