Remarkably, autophagy blockage by CQ provoked an increase in the effect of lapatinib on tumor growth reduction (p < 0.001) only in GSDMB-expressing (shNTC) tumors, compared to lapatinib alone, while no such effect was observed in GSDMB-silenced (shGB1, shGB2) tumors. This evidence concerns the gene GSDMB and neoplasm.