On the other hand, GSDMB full-length protein (GSDMB-FL) exhibits additional functions in pathogenesis, including cell motility and epithelial barrier repair during inflammatory bowel disease [11], transcriptional control of disease-associated genes in asthma [10], promoting invasion and/or metastasis of cancer cells [13, 14, 45], metabolism regulation in tumors [45], and cancer therapy resistance [12, 14]. The gene discussed is GSDMB; the disease is inflammatory bowel disease.