GSDMB and gastric neoplasm: Here, to address whether GSDMB also plays a role in the clinical behavior of gastric tumors, we first observed that strong cytoplasmic and nuclear GSDMB staining (Fig. 1A and Supplementary Table 1) associated statistically with HER2 positive status (GSDMB high expression in 18/31 (58.1%) of HER2-positive and 8/28 (29%) of HER2-negative tumors; p = 0.023).