In paired pancancer samples for 33 cancer types, TMSB10 expression was found to be significantly higher in tumor tissues than in their corresponding normal tissues in all cancers except for KICH (Fig. 1I), while other genes showed heterogeneous expression patterns (Additional file 1: Fig. S3 A–F), suggesting that TMSB10 might play vital roles in regulating cancer hallmarks and the immune response in cancers. The gene discussed is TMSB10; the disease is cancer.