Chen et al. [24] found that PTEN deficiency, which was also upregulated in TMSB10-high GBM samples, could increase macrophage infiltration via the YAP1-LOX-β1 integrin-PYK2 axis, and the infiltrated macrophages in turn secreted SPP1 to support GBM survival. The gene discussed is PTEN; the disease is glioblastoma.