We found that TMSB10 was positively correlated with the enrichment scores of typical cancer hallmarks, the inflammatory response and tumor malignancy markers (PCNA, a proliferation index, and VIM and CD44, markers of invasion) in a wide range of cancer types, especially in lower grade glioma (LGG), glioblastoma (GBM), bladder cancer (BLCA) and liver hepatocellular carcinoma (LIHC) (Fig. 2A). This evidence concerns the gene TMSB10 and central nervous system cancer.