Considering the heterogeneity of different grades of gliomas, we compared the expression levels of TMSB10 in different grades of gliomas in the Chinese Glioma Genome Atlas (CGGA), TCGA and Gravendeel datasets and found that TMSB10 expression was positively correlated with tumor grade, and the expression level was highest in GBM (WHO grade IV glioma) (Fig. 3A). Here, TMSB10 is linked to central nervous system cancer.