Thirteen genes (NLRP2, TP63, CYCS, CASP9, IL1A, CHMP2B, CHMP4C, CHMP3, IL1B, CHMP7, TIRAP, CASP6, and GSDME) were downregulated and 31 other genes (CHMP2A, IRF2, CHMP6, TP53, GPX4, CASP3, PLCG1, NOD1, GSDMD, CASP8, CHMP4A, IL18, IL6, IRF1, NLRP1, CASP4, BAX, NLRP3, NLRP6, GSDMA, CASP1, GSDMB, NLRC4, PYCARD, NLRP7, GSDMC, NOD2, GZMB, CASP5, AIM2, GZMA) upregulated in tumour tissue samples. The gene discussed is GSDMD; the disease is neoplasm.