The results showed the copy number of these prognosis-related PRGs to be associated with the immune microenvironment in ccRCC, with AIM2, ELANE, GSDMB, NLRP1, and NOD2 mutations inhibiting infiltration of some kinds of immune cells (Fig. 6A–F). The gene discussed is AIM2; the disease is nonpapillary renal cell carcinoma.