Previous studies have showed the usefulness of blood biomarkers such as tau phosphorylated at threonine 181 (p-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP), in the diagnosis and prognosis of dementia, with comparable or even better performance than positron emission tomography (PET) and CSF biomarkers [32–34]. This evidence concerns the gene GFAP and dementia.