The newly introduced messenger-RNA vaccines (Pfizer-BioNTech and Moderna) for COVID-19, utilize a novel technology, using lipid nanoparticles formulated in nucleoside-modified mRNA that encodes the prefusion spike glycoprotein of COVID-19, aiming to produce spike proteins by the recipient cells after the entrance of the mRNA into their cytoplasm and subsequently an anti-spike protein immune response [3]. This evidence concerns the gene CHMP5 and COVID-19.