We found that GO:0,060,337 (type I interferon signaling pathway), GO:0,051,607 (defense response to virus), GO:0,009,615 (response to virus), GO:0,045,071 (negative regulation of viral genome replication), GO:0,060,333 (interferon-gamma-mediated signaling pathway), GO:0,001,730 (2'-5'-oligoadenylate synthetase activity), GO:0,003,725 (double-stranded RNA binding), and GO:0,005,829 (cytosol) played critical roles in the development and progression of BLCA. The gene discussed is IFNG; the disease is bladder transitional cell carcinoma.