Recently, large population-based and family-based targeted sequencing studies have established that PVs in RAD51C, RAD51D and BARD1 are associated with BC risk15 16 and that PVs in PALB2 are associated with EOC risk.17 18 In addition, analysis of the tumour characteristics in the BRIDGES study has provided age-specific estimates of the distributions of tumour characteristics for PV carriers in all established susceptibility genes.19 This evidence concerns the gene RAD51C and breast cancer.