PGR and neoplasm: In addition, the models incorporate breast tumour heterogeneity by considering the distributions of tumour oestrogen receptor (ER) and triple-negative (TN) (ER, progesterone receptor and human epidermal growth factor receptor 2 negative) status for BRCA1 and BRCA2 PV carriers and the general population.12 13 Both models are freely available to healthcare professionals via the CanRisk webtool (www.canrisk.org) and are widely used by healthcare professionals.14