This work has extended the multifactorial BOADICEA BC and EOC risk prediction models (BOADICEA v6 and the Ovarian Cancer Model v2), employing a synthetic approach.23 The explicit effects of PVs in RAD51C, RAD51D, BARD1 and PALB2, which have now been established as BC and/or EOC susceptibility genes15–17 and are commonly included on cancer gene panels, are now included in the models. The gene discussed is PALB2; the disease is breast cancer.