Lactis are protective in the innate TRUC model of IBD.58 Some organisms that are potentially protective against intestinal inflammation, including Parabacteroides distasonis and Bacteroidetes acidifaciens exhibited increased abundance in regions of the TRAG colon, compared to the RAG1−/− colon.59–61 The pathophysiology of innate colitis in TRAG mice is distinct from other innate immune models of IBD. Here, RAG1 is linked to colitis.