CD40 and colitis: The colitis in TRUC mice is transmissible and markedly reduced in C57Bl/6 mice, whereas TRAG colitis is not transmissible and is highly penetrant and early onset in C57Bl/6 mice.2,62 Innate colitis in RAG−/− mice induced by anti-CD40 treatment or H. hepaticus infection is acute, systemic, and driven by ILC3 cells which is not the case for TRAG mice.52 Thus, differences in the gut microbiome or response to the microbiome between these innate models of IBD may reflect differences in the nature of the innate inflammation or the response of the innate system to gut microbes.