TCR‐linked ERK activation has been implicated in the positive and negative selection of T lymphocytes in the thymus as well as in the development of thymic lymphoma initiation and progression.[31] ERK phosphorylation was further increased in DP thymocytes of Ripk3−/− mice bearing thymic lymphoma, indicating that RIPK3 deficiency results in loss of regulation for ERK activation. The gene discussed is RIPK3; the disease is thymus lymphoma.