CXCL12 and lung cancer: Additionally, they proposed that CXCL12/CXCR4 signaling pathways, EIF4EBP1, EGFR, ERBB2 and VEGFR2 involved in lung cancer brain metastasis, L1CAM‐mediated ERK1/2 signaling, EGFR and KRAS involved in lung cancer bone metastasis of and type‐1 insulin‐like growth factor receptor (IGF‐1R) involved in lung cancer liver metastasis19.