Additionally, they proposed that CXCL12/CXCR4 signaling pathways, EIF4EBP1, EGFR, ERBB2 and VEGFR2 involved in lung cancer brain metastasis, L1CAM‐mediated ERK1/2 signaling, EGFR and KRAS involved in lung cancer bone metastasis of and type‐1 insulin‐like growth factor receptor (IGF‐1R) involved in lung cancer liver metastasis19. This evidence concerns the gene MAPK3 and lung cancer.