TGFB1 and neoplasm: In a spontaneous murine model of melanoma, Toh and colleagues have shown for the first time that MDSCs use TGF-β, epidermal growth factor, and hepatocyte growth factor to induce EMT and to support metastasis and that MDSC depletion reverts this phenotype [125], confirming TGF-β as a critical target to abolish MDSC’s pro-tumour features.