In addition, a recent report demonstrates that the human BAF SS18-SSX (synovial sarcoma X breakpoint) protein, a fusion protein that is a driver of synovial sarcoma, directs binding of the SWI/SNF complex to H2A K119-ubiquitinated nucleosomes in heterochromatin regions by tethering the SRM to the distal acidic patch of nucleosomes to de-repress gene expression (42). The gene discussed is SMARCA1; the disease is synovial sarcoma.