The RACK1 gene can modulate neurodegeneration by promoting ERK degradation in Machado-Joseph disease (MJD) and Huntington’s disease (HD) models and participates in the process of neuronal differentiation by regulating SCN1A expression (Adams et al., 2011; Dong et al., 2014; Xie et al., 2021). Here, SCN1A is linked to Machado-Joseph disease.