NFE2L2 has previously been implicated in the development of Alzheimer’s pathology in DS (Sharma et al., 2020; Lanzillotta et al., 2021) and decreased mRNA and protein levels of BDNF have long been linked to deficits in learning and memory in mouse models of DS (Bimonte-Nelson et al., 2003; Bianchi et al., 2010; Parrini et al., 2017). This evidence concerns the gene BDNF and Dravet syndrome.