Second, in the early 1970s, Malone and Suzuki demonstrated an extremely low or lost activity for a lysosomal enzyme used for degrading galactosylceramide (GalCer) in GLD, the kind of lysosomal enzyme known as galactocerebrosidase or galactosylceramide β-galactosidase (GALC). Here, GALC is linked to Krabbe disease.