Until now, a total of 296 GALC gene mutations related to GLD have been cataloged in the Human Gene Mutation Database (HGMD), including missense mutations, non-sense mutations, deletion, and insertion (Figure 1), and the sites and types of gene mutations have regional and racial variation (Rafi et al., 1996; Kleijer et al., 1997; Xu et al., 2006; Zayed, 2015). The gene discussed is GALC; the disease is Krabbe disease.