Although all DYRKs have been involved in different diseases, including congenital malformations, cancer, and virus infection (Boni et al., 2020; Lindberg and Meijer, 2021; Yoshida and Yoshida, 2022), different lines of evidence suggest that DYRK1A and DYRK2 are the most relevant forms for human disease. Here, DYRK2 is linked to cancer.