Mechanistically, the mitigative effects of AMPK signal on lipid metabolism disorders, oxidative stress and inflammatory response triggered by PO are achieved through activating the nuclear factor erythroid 2-related factor 2 (NRF-2)/kelch-like ECH-associated protein 1 (KEAP1) pathway and inhibiting the NF-κB pathway in primary chicken hepatocytes. The gene discussed is NFE2L2; the disease is Disorder of lipid metabolism.