Recently, our series studies had confirmed that activated AMPK can prevent the occurrences of NAFLD/NASH induced by high-fat/high-cholesterol diets in rodents or the lipid metabolism disorders, oxidative stress and inflammatory response challenged by palmitic acid/oleic acid stimulation in hepatocytes (Li et al., 2005; Li et al., 2021). The gene discussed is PRKAA1; the disease is Disorder of lipid metabolism.