Many researchers, including our laboratory, have found that the activation of AMPK signal can protect against the occurrence and development of NAFLD that presented as mitigative effect on the hepatic steatosis, inflammatory response and oxidative stress in mammals (Hu et al., 2021; Li et al., 2021; Wan et al., 2021). Here, PRKAA1 is linked to metabolic dysfunction-associated steatotic liver disease.