More importantly, we found that blocked AMPK signal by AMPK inhibitor compound C exacerbated the lipid metabolism disorders, oxidative stress and inflammatory response triggered by PO in primary chicken hepatocytes; conversely, the lipid metabolism disorders, oxidative stress and inflammatory response challenged by PO were obviously alleviated by activation of AMPK signal using AMPK activator AICAR in hepatocytes. Here, PRKAA1 is linked to Disorder of lipid metabolism.