Similarly, Huang et al. (2018) found that the SBP, renal fibrosis area, and the fibrotic-related protein levels of TGFβ-1, p-Smad2/3, and CTGF were significantly decreased in the moderate-intensity exercise training group compared to the SHR group, but our current findings showed adverse effect in the SHR-H group. The gene discussed is SMAD2; the disease is renal fibrosis.