Our hypothesis is that high-intensity exercise training (HIET) could produce high lactic acid that may aggravate renal inflammatory conditions and activate TRPV4-TGFβ1-Smad2/3-CTGF-mediated renal fibrotic pathways in hypertension, which might cause adverse effects (renal damage and fibrosis). The gene discussed is SMAD2; the disease is Hypertension.