39sahnchuConversely, other studies have also pointed out STAT3 drives cardiac hypertrophy and heart failure by impairing mitochondrial bioenergetics (Zhuang et al., 2022), and STAT3 induces cardiac fibroblast activation and cardiac fibrosis (Su et al., 2017; Bao et al., 2020). Here, STAT3 is linked to cardiac hypertrophy.