Furthermore, the present study demonstrated for the first time that combined exercise training increased the pulmonary levels of adiponectin in non-obese and overweight women and the levels of IL-10 in non-obese and obesity grade I women, revealing that such anti-inflammatory effects of exercise training are not limited to the systemic circulation, but also reaches the lungs, counter-parting the effects of overweight and obesity. This evidence concerns the gene IL10 and obesity due to melanocortin 4 receptor deficiency.