Of note, the study by Matsubara et al., 2014, demonstrated that chronic exercise increases plasma levels of Klotho, resulting in better functional arterial stiffness in postmenopausal women, an event with similar issues concerning the pathobiology of lung fibrosis (i.e., inflammation and smooth muscle proliferation and increased synthesis and accumulation of extracellular matrix proteins) (Mencke et al., 2017). This evidence concerns the gene KL and pulmonary fibrosis.