In addition, the treatment of Dendrobium officinale polysaccharides at the dose of 1 μg/mL in Sjogren's syndrome model could reduce the abnormal infiltration and apoptosis of lymphocytes, attenuate the dysfunction of AQP5, and induce the translocation of AQP5 by activating M3 muscarinic receptors, which indicated its ability to improve the immunity [39, 49]. Here, AQP5 is linked to Sjogren syndrome.