The mouse model with Sjogren's syndrome further demonstrated the underlying mechanism that Dendrobium officinale polysaccharides (20 mg/mL) could reduce the expression of proinflammatory cytokines like tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6, which attenuated the immune-mediated inflammation and maintained the balance of inflammatory cytokines [39]. This evidence concerns the gene TNF and Sjogren syndrome.