TNF and rheumatoid arthritis: Additionally, the KEGG pathways were most enriched in apoptosis and inflammatory-associated pathways, such as the TNF signaling pathway, osteoclast differentiation, IL-17 signaling pathway, apoptosis, Th17 cell differentiation, Th1 and Th2 cell differentiation, rheumatoid arthritis, and NF-kappa B signaling pathway.