The results of this study clearly showed that PD can restore CP-induced autophagy flux blocking in both CP-treated HK-2 cells in vitro and CP-AKI animals in vivo, which were manifested by the increase in LC3 II and autophagolysosome/autophagosome ratio, and the decrease in p62 accumulation; however, this effect was blocked by CQ. This evidence concerns the gene SQSTM1 and acute kidney injury.