Li et al. [32] confirmed that overexpression of SIRT6 attenuated CP-AKI by inhibiting extracellular signal-regulated kinase 1/2 signaling; Fan et al. [50, 51] confirmed that isoorientin and daphnetin can alleviate CP-AKI through antioxidative stress and antiapoptosis via activating the SIRT1/SIRT6/nuclear factor erythroid 2-related factor 2 pathway, but the relationship between SIRT6 and autophagy has not been reported in CP-AKI. The gene discussed is MAPK3; the disease is acute kidney injury.