In this study, the correlation between autophagy flux and SIRT6 in the nephroprotection of PD was investigated in in vivo and in vitro models of CP-AKI, with the following highlights: (1) It was first confirmed that PD could alleviate CP-AKI by restoring autophagy flux; (2) it was confirmed for the first time that the inhibition of SIRT6 pathway reverses the recovery effect of PD on CP-blocked autophagy flux, suggesting the potential effect of SIRT6-mediated autophagy flux on the nephroprotection of PD in CP-AKI. This evidence concerns the gene SIRT6 and Parkinson disease.