SQSTM1 and Parkinson disease: As shown in Figures 6(b) and 6(c), in CP-AKI mice, the PD-increased degradation of p62 (a selective substrate of autophagy) was inhibited by CQ, and the expression of LC3 II was increased, suggesting that blocking lysosomal degradation by CQ abolished the recovery effect of PD on autophagy flux.