LOX and malignant glioma: Li et al. (2018) has revealed that LOXL1 is highly expressed in tissue samples of malignant gliomas and LOXL1 accelerates cell proliferation via Wnt/β-catenin signaling. In respect of LOX, one of the major subtypes of LOXs, it has been demonstrated that it is positively correlated with the malignant grade of astrocytomas (da Silva et al., 2015).