Regarding the roles of LOXL1-4 in the glioma, LOXL1 is also demonstrated to exhibit antiapoptotic activity (Yu et al., 2020) and promote glioma cell proliferation (Li et al., 2018) while the facilitation of cell invasion for LOXL3 is observed in glioma cell line U87MG (Laurentino et al., 2021). Here, LOXL3 is linked to central nervous system cancer.