The results indicated that the mRNA (Figure 11A) and protein expressions (Figures 11B,C) of LOX, LOXL1, LOXL2, and LOXL3 were significantly upregulated in these glioma cells than in HEB cell line while the expressions of LOXL4 at mRNA and protein level were not determined in these cell lines (data not shown). Here, LOXL4 is linked to central nervous system cancer.