In terms of prognosis according to different glioma grades (Figures 5B,E,H,K,N) and ROC curve analysis (Figures 5C,F,I,L,O) of predictive values with distinct LOXs expressions, it was also validated in CGGA-693 dataset although the significance of the prognosis was observed in the grade II glioma patients with high level of LOX or LOXL1 which was not consistent with those findings displayed in CGGA-325 cohort. This evidence concerns the gene LOXL1 and central nervous system cancer.