Considering the critical role of LOXs in the carcinogenesis and tumor progression (Liburkin-Dan et al., 2022), we firstly explored whether LOXs were associated with the pathological factors of the gliomas, including world health organization (WHO) grade, isocitrate dehydrogenase (IDH) mutation, 1p/19q co-deletion status, age, gender, radiotherapy status and O-6-methylguanine DNA methyltransferase (MGMT) methylation status (Louis et al., 2016). Here, IDH3A is linked to central nervous system cancer.