In agreement with our proposal, previous studies have shown that MA ingredients, including Apigenin, luteolin, quercetin, ferulic acid, chlorogenic acid, isoorientin, naringenin, and resveratrol, ameliorate hyperglycemia and hyperlipidemia through activation of the AMPK signaling pathway and SIRT1 (Ong et al., 2012; Jin et al., 2015; Tsai et al., 2018; Joshi et al., 2019; DiNicolantonio et al., 2022). This evidence concerns the gene PRKAA2 and hyperlipidemia.