These findings strongly suggest that 1) NAPRT genes are amplified and overexpressed in a subset of common cancers; 2) NAPRT plays a role in cancer cells’ (e.g., ovarian and pancreatic cancer cells) energy status, cell growth, metabolism, DNA repair processes, proliferation regulation and protein synthesis; 3) Resistance to NAMPT inhibitors in previously tried clinical trials may be overcome by NAPRT inhibition (Piacente et al., 2017). The gene discussed is NAPRT; the disease is cancer.