The Preiss-Handler pathway is commonly observed to be dysfunctional in cancer cells owing to the loss of expression of nicotinic acid phosphoribosyltransferase domain containing 1(NAPRT1), which can help metabolize nicotinic acid (NA) to NAD (Watson et al., 2009; O’Brien et al., 2013; Shames et al., 2013). The gene discussed is NAPRT; the disease is cancer.