The cellular components were primarily concentrated in cytoplasmic vesicle lumen, secretory granule lumen, ficolin-1-rich granule lumen, membrane raft, vacuolar lumen, lytic vacuole, and lysosome; according to the results of the KEGG pathway enrichment analysis, most were involved in the MAPK signaling pathway, PI3K-Akt signaling pathway, the Ras signaling pathway, focal adhesion, fluid shear stress, atherosclerosis, Rap1 signaling pathway, and the chemokine signaling pathway. The gene discussed is AKT1; the disease is atherosclerosis.