TP53 and bacterial infectious disease: What’s more, Singh et al. reported that the mutation of amino acid 47 in human TP53 caused defects in p53-induced ferroptosis, resulting in massive intracellular iron accumulation in macrophages, which would lead to M2-polarization of macrophages, eventually helping resist Plasmodium infection but also promoting bacterial infections such as Listeria (Singh et al., 2020).