Lipoxygenase (LOX) catalyzes the production of lipid peroxides, as proof, Arachidonate 12-Lipoxygenase (ALOX12), an isoform of the mammalian lipoxygenase family, can inhibit p53-regulated ferroptosis via inhibiting lipid synthesis function by specifically binding to SLC7A11, which abolishes the function of p53 suppressing tumor growth through ferroptosis (Chu et al., 2019). This evidence concerns the gene TP53 and neoplasm.