These data showed that the phosphorylation and/or expression of the key pro-oncogenic RTKs was activated in SH-SY5Y and SK-N-BE(2) neuroblastoma cells; specifically EGFR, PDGFRβ, and IGF-1R were inhibited by both thiosemicarbazones and TKIs. This evidence concerns the gene PDGFRB and neuroblastoma.