In addition to the inhibition of the corresponding targets, we also identified interesting off-target effects of GEF and LAP on PDGFRβ activation and the effect of SUN on EGFR phosphorylation (at the Tyr1148 residue) in both SH-SY5Y and SK-N-BE(2) neuroblastoma cell lines, which served as the models for detailed analyses of the molecular effects of combined treatments. The gene discussed is EGFR; the disease is neuroblastoma.