As suggested for other cancer types (Kovacevic et al., 2016; Menezes et al., 2017; Macsek et al., 2022), a thiosemicarbazone-mediated decrease in EGFR observed in SH-SY5Y cells in the present study may be attributed to NDRG1 upregulation. This evidence concerns the gene NDRG1 and cancer.