There are no studies that have focused on this type of activity of GEF or LAP; however, the multikinase inhibitor SUN has been previously shown to target a number of unconventional RTKs, including EGFR, FGFR, TrkA, and TrkB, in neuroblastoma cells (Calero et al., 2014). This evidence concerns the gene NTRK2 and neuroblastoma.