TP53 and cancer: Pharmacologically, a few numbers of signaling pathways or essential conditions for example, “mitogen-activated protein kinases (MAPKs), Wnt/β-catenin, PI3K/Akt, and p53,” have been documented to participate in the cancer prevention process by tetrandrine (Meng et al., 2004; NOMURA et al., 2007; Wu et al., 2010).