In an HCC mouse model with hepatic steatosis combined with an HCC cell line (HepG2 and SMMC-7721), osthole (244 mg/kg) exerted HCC antilipogenic and antiproliferative activities by suppressing the phospho-protein kinase B (AKT) (Thr308)/ribosomal protein S6/fatty acid synthase axis and extracellular signal-regulated kinase phosphorylation in vivo and in vitro (Mo et al., 2020). Here, AKT1 is linked to fatty liver disease.