WNK2 and ovarian cancer: As overall IC50 values for osthole in ovarian cancer cells were 20 μM through targeting the PI3K/mitogen-activated protein kinase signaling pathway to facilitate endoplasmic reticulum–mitochondrial axis-mediated anticancer mechanisms and exert calcium-dependent pharmacological potential in ovarian cancer cell lines (ES2, OV90; Bae et al., 2021).