TRPV1 and osteoarthritis: First generation TRPV1 antagonists caused transient increase in body temperature and decrease in noxious heat sensation. Second generation drugs are attempting to overcome these limitations. AZD-1386 antagonist did not show efficacy in osteoarthritis pain (Miller et al., 2014; Moran & Szallasi, 2018; Fernández-Carvajal et al., 2020)