One more Cl− channel found in macrophages is transmembrane protein 16A, TMEM16A (Shi et al., 2020), which has been reported to mediate microRNA9-induced TGF-β/Smad2 signalling implicated in LPS-induced sepsis (Zhen et al., 2019; Sui et al., 2020; Bai et al., 2021). The gene discussed is ANO1; the disease is Sepsis.