When we compared median TNF-α values of the three groups at end of the study with their baseline values, we found that administration of rutin/vitamin C combination (Ruta C) causes a reduction of TNF-α levels in 50% of the patients from 210 ng/L to 40 ng/L indicating the ability of rutin to alleviate the inflammatory response and manifested itself to produce a small synergistic effect with vitamin C, when given together as a combination, and also as a promise anti-inflammatory treatment attenuating inflammation and oxidative stress in HD patients. Here, TNF is linked to Huntington disease.