Abbreviations: TPC, treatment physician’s choice; BC, Breast Cancer; ABC, advanced breast cancer; LA, locally advanced; HR, Hormone Receptor; TNBC, triple-negative breast cancer; LM, leptomeningeal metastasis; OS, overall survival; ORR, objective response rate; PFS, progression free survival; DCR, disease control rate; pCR, pathological complete response; PR, partial response; SD, stable disease; DTL, Dose Limiting Toxicity; AE, Adverse Events; MTD, maximal tolerance dose; RP2D, recommended phase II dose; NA, not available. Here, NR4A1 is linked to breast cancer.