AMPK, a crucial regulatory protein keeping the balance of systemic energy metabolism, is essential for maintaining glucose balance and has been proven to be a druggable and potentially therapeutic target for the treatment of IR and T2DM (Entezari et al., 2022), and its activation promotes the translocation of GLUT4 vesicles from intracellular membranes to the cell surface (Zhang et al., 2018b; Chen et al., 2021b; Shrestha et al., 2021). Here, SLC2A4 is linked to type 2 diabetes mellitus.