A series of studies have demonstrated that PI3K/AKT signaling pathway is actively involved in the migration process of metastatic cancer cells, including the regulation of cytoskeleton-remodeling proteins (such as Vimentin and F-actin) and EMT–activating proteins (such as Snail and Twist) that specifically regulate cell motility (Xue and Hemmings, 2013; Lamouille et al., 2014). Here, PROS1 is linked to cancer.