Epithelial-to-mesenchymal transition (EMT) and motility of cancer cells are associated with transendothelial migration, and these processes are regulated by the PI3K/AKT and FAK/Paxillin pathways (Xue and Hemmings, 2013; Lamouille et al., 2014; Yu et al., 2015). The gene discussed is PTK2; the disease is cancer.