CDH2 and cancer: The EMT process is very complex, mediated by transcription factors such as SNAIL, ZEB, and Twist, activating mesenchymal markers (including N-cadherin, β-catenin, Fibronectin, and Vimentin) that play an important role in enhancing cancer cell motility (Thiery and Sleeman, 2006; Mani et al., 2008).