NLRP3 and colitis: MCC950 is well known as an NLRP3-specific inhibitor, showing a promising therapeutic effect in a variety of NLRP3-dependent immunopathological mouse models, including colitis, steatohepatitis, etc., but it was withdrawn from phase II clinical trial for the treatment of rheumatoid arthritis due to hepatotoxicity (Mangan et al., 2018).