Most types of TCMs, including TCM formulas, extracts, and its natural products, have been used in treating NAFLD and exhibit a promising treatment efficacy via modulating a variety of risk signals in the process of NAFLD, such as oxidized lipids, DAMPs, and ROS, resulting result in NLRP3 expression in liver tissue through TLR4 (Farrell et al., 2018; Wang et al., 2020; Zhang et al., 2020). Here, NLRP3 is linked to metabolic dysfunction-associated steatotic liver disease.