Moreover, both NLRP3 inflammasome components, deficient or treated with NLRP3 inhibitors, attenuated the inflammation, liver fibrosis, and liver cell death in a mouse model, which further demonstrated the role of the NLRP3 inflammasome in NAFLD (Dixon et al., 2013; Li et al., 2022). The gene discussed is NLRP3; the disease is Hepatic fibrosis.