Over-activation of the NLRP3 inflammasome has also been found in trichloroethene- and ConA-induced autoimmune hepatitis mice models, indicating that the inflammasome activation-dependent IL-1β and pyroptosis contributed to exacerbating the liver injury (Luan et al., 2018; Wang et al., 2019b). Here, NLRP3 is linked to autoimmune hepatitis.