PIWIL4 and cancer: Figures 13F–K and Supplementary Figure S7 illustrated the optimal docking space conformation and interaction force of each drug to PIWIL4 protein. The detailed docking scoring results were provided in Supplementary Table S1. Obviously, SID 26681509 had the best binding conformations to PIWIL4 protein. To further assess the influences of PIWIL4 expression on drug sensitivity, we examined the relationship between multiple drug activities and PIWIL4 expression in NCI-60 cancer cell lines (Supplementary Figures S8, S9).