Wang and Zhao (Wang and Zhao, 2016) reported that Calycosin had a beneficial effect on the improvement, prevention, and treatment of DM-related cognitive deficits by affecting oxidative stress, synaptic function, and the phosphatidylinositol 3-hydroxy kinase/protein kinase B/glycogen synthase kinase-3β (PI3K/AKT/GSK-3β) pathway, and contributed to the improvement of the pathologic process of AD. Here, GSK3B is linked to diabetes mellitus.