NFATC1 and neoplasm: Liu et al. (2021)’s experiment demonstrated that TBMS I can also realize its anti-tumor effect by improving anti-tumor T cell immunity. B. paniculatum has inhibiting effect both on humoral and cellular immunity (Huang et al., 1992); the further test indicated that it markedly inhibit T lymphocyte proliferation in vitro and T cell-mediated delayed type hypersensitivity (DTH) in vivo, and the mechanism may be concerned in depressing the activation of NF-kB, NFAT2 and AP-1 signal transduction pathways (Huang et al., 1992).