Modulation of the JNK pathway has been recognized as an effective avenue to treat cancers, including oral tumors, osteosarcoma, and colorectal cancer (Fu et al., 2020; Kon-Young Ji 2021; Liu et al., 2021), especially AML (Torres et al., 2010; Bomfim et al., 2019; Tian et al., 2019). Here, MAPK8 is linked to cancer.