BMSCs secrete soluble factors that enhance the survival of MM (Di Marzo et al., 2016), furthermore co-culturing BMSCs with MM cells increases resistance against chemotherapeutic agents and enhances the expression of stemness genes such as Nanog, SOX2, and OCT4 (Zhao et al., 2017; Matula et al., 2021). This evidence concerns the gene SOX2 and Miyoshi myopathy.