INS and hyperinsulinism: Based on the mean + 2 SD values for insulin and HOMA-IR observed in Table 3, as well as a ROC curve co-ordinates, we defined the following diagnostic cut-offs for hyperinsulinemia (and raised HOMA-IR): Men ≥ 8 mU/L (sensitivity: 82.4% and specificity: 58%) and HOMA-IR ≥ 1.5 (sensitivity: 91.3% and specificity: 51%) and Women ≥ 10 mU/L (sensitivity: 78.6% and specificity: 72.5%) and HOMA-IR ≥ 2.0 (sensitivity: 83.9% and specificity: 70.2%).