INS and metabolic syndrome: In summary, studies to evaluate the benefits of an early approach of patients with fasting insulin values above normal cut-offs, i.e., 8 mU/L in men and 10 mU/L in women (and/or HOMA-IR upper limits of 1.5 and 2.0), despite the number of diagnostic criteria for MetS (Level 1 MetS) to reduce cardiovascular events are necessary.