Different stimuli related to endothelial dysfunction, such as vascular stress, oxysterols, and inflammation, have been reported to upregulate Eng gene transcription via transcription factors Kruppel Like Factor 6 (KLF6), liver X receptor alpha (NR1H3) and NF-κB p65 (RELA) (33, 36–38). The gene discussed is RELA; the disease is endothelial dysfunction.