The fourprimary indications for keratoplasty in this category were keratoconus (44,63.8%), followed by non-specified corneal opacities (8, 11.6%), active cornealinfections (6, 8.7%), and aphakic/pseudophakic bullous keratopathies (6, 8.7%).PKP (49, 71%) was the most common surgical procedure in this group, followed byDALK (19, 27.5%) and ALK (1, 1.4%). This evidence concerns the gene ALK and bullous pemphigoid.