Through LASSO, risk score evaluation, and Cox analyses, 7 prognostic mRNAs, ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1, were identified and applied to design the predictive nomogram for CRC prognosis, and the nomogram was proved to have a good prediction ability. This evidence concerns the gene SYT1 and colorectal carcinoma.