AKT1 and cancer: The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (Fig. 2 and Supplementary Fig. S3) indicated activation of metabolic pathways, viral infection-related pathways, pathways in cancer, MAPK, PI3K-Akt signaling pathway, cell cycle pathway, cellular senescence pathway, and DNA replication pathways in HBV- and YAP-overexpressed cell groups compared with the mock-transfected cells (Fig. 2A and B).