BRAF and neoplasm: Sastre-Marcos (2015) reported that microcalcification and hypoechogenicity were found to be two independent factors correlated with BRAF mutations. Our results were consistent with their findings, with microcalcification, hypoechogenicity, lobulated margins, and an aspect ratio of greater than 1 being independent risk factors for BRAF mutations. However, it was also shown that BRAF V600E mutations were not associated with tumor size, tumor border, or calcification (Li et al., 2017).