In addition to STAT3, NPM1 and CEBPA confer to notable class II mutations while DNA-methylation–related genes DNMT3A, TET2, and IDH-1 and IDH-2 contribute to the class II mutation group for AML, which are found in about 27% and more than 40% of AML cases, respectively (Takahashi, 2011; Klein et al., 2018). Here, NPM1 is linked to acute myeloid leukemia.